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The Obama administration and European governments have set the end of the year as a deadline for the transfer of the uranium out of Iran and for progress in the overall negotiations. But the administration must consider whether it makes sense to grant the regime two more months of grace. On Tuesday, after all, Supreme Leader Ayatollah Ali Khamenei publicly rejected the overtures he said he had received from President Obama, declaring that negotiating with the United States was "naive and perverted." On Wednesday, the opposition protesters chanted: "Obama, Obama -- either you're with them, or with us." Sooner rather than later, Mr. Obama ought to respond to those messages.