The annual Munich Security Conference, which brings together a dozen world leaders and about 50 top diplomats and defense officials, starts on Friday for the 45th time with one item paramount on its agenda: the United States-led world order, given the troubles in Afghanistan and Iraq and the ongoing impasse with Iran. The US has sent a high-ranking delegation led by Vice President Joe Biden and the special representative for Afghanistan and Pakistan, Richard Holbrook. They are expected to seek informal dialogue with Iran, represented by Foreign Minister Manouchehr Mottaki and parliament speaker Ali Larijani.